EVIDENCE

SureAdhere research & publications.

27 peer-reviewed studies supporting video directly observed therapy, from landmark randomized controlled trials to real-world implementation research across the US, Europe, Asia, and beyond.

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SureAdhere evidence: peer-reviewed research
27
Peer-reviewed publications
10+
Countries represented in research
WHO
Global treatment guidelines informed
CDC
US treatment guidelines updated
FULL EVIDENCE BASE

Peer-Reviewed Publications

These peer-reviewed studies, spanning RCTs, cohort studies, and real-world implementation research, form the scientific foundation behind SureAdhere and have directly informed WHO and CDC treatment guidelines.

Location
Study Type
01
RCT
In-Person vs Electronic Directly Observed Therapy for Tuberculosis Treatment Adherence: A Randomized Noninferiority Trial
Burzynski J, Mangan JM, Lam CK, et al. JAMA Netw Open. 2022;5(1):e2144210.
Electronic DOT was non-inferior to in-person DOT (−2.6% difference) across 4 clinics and 216 patients, providing key evidence for inclusion of eDOT in the standard of care.
Jan 2022
USAMulti-state
02
Feasibility and Acceptability of Asynchronous VOT Among Patients with MDR-TB
Casalme DJO, Marcelo DB, et al. Int J Tuberc Lung Dis. 2022;26(8):760-765.
Aug 2022
PhilippinesAsia
03
Real-world Implementation of Video-Observed Therapy in an Urban TB Program in The United States
Perry A, Chitnis A, Chin A, et al. Int J Tuberc Lung Dis. 2021;25(8):655-661.
Aug 2021
USAUrban
04
Assessing Private Provider Perceptions and The Acceptability of Video Observed Treatment Technology for Tuberculosis Treatment Adherence in Three Cities Across Vietnam
Nguyen LH, Tran PTM, Dam TA, et al. PLoS One. 2021;16(5):e0250644.
May 2021
VietnamAsia
05
RCT
Video-observed Therapy and Medication Adherence for Tuberculosis Patients: Randomised Controlled Trial in Moldova
Ravenscroft L, Kettle S, Persian R, et al. Eur Respir J. 2020;56(2):2000493.
Aug 2020
MoldovaEurope
06
Transforming Essential Services for Tuberculosis During the COVID-19 Pandemic: Lessons from New York City
Burzynski J, Macaraig M, Nilsen D, Schluger NW. Int J Tuberc Lung Dis. 2020;24(7):735-736.
Jul 2020
USANew York City
07
Video Directly Observed Therapy for Supporting and Monitoring Adherence to Tuberculosis Treatment in Uganda: A Pilot Cohort Study
Sekandi JN, Buregyeya E, Zalwango S, et al. ERJ Open Res. 2020;6(1):00175-2019.
82.2% of expected videos received; median adherence 85%; 92% of patients reported being very satisfied. VDOT proved feasible and acceptable in a resource-limited African setting.
Mar 2020
UgandaAfrica
08
Evaluation of Recorded Video-Observed Therapy for Anti-Tuberculosis Treatment
Garfein RS, Liu L, Cuevas-Mota J, et al. Int J Tuberc Lung Dis. 2020;24(5):520-525.
May 2020
USACalifornia
09
A Comprehensive App That Improves Tuberculosis Treatment Management Through Video-Observed Therapy: Usability Study
Guo X, Yang Y, Takiff HE, et al. JMIR Mhealth Uhealth. 2020;8(7):e17658.
Jul 2020
ChinaAsia
10
Perceptions and Acceptability of Digital Interventions Among Tuberculosis Patients in Cambodia: Qualitative Study of Video-Based Directly Observed Therapy
Rabinovich L, Molton JS, Ooi WT, Paton NI, Batra S, Yoong J. J Med Internet Res. 2020;22(7):e16856.
Jul 2020
CambodiaAsia
11
Requiring Smartphone Ownership for mHealth Interventions: Who Could Be Left Out? Lessons from New York City
Bommakanti KK, Smith LL, Liu L, et al. BMC Public Health. 2020;20(1):81.
Jan 2020
USANew York City
12
Cost of Tuberculosis Therapy Directly Observed on Video for Health Departments and Patients in New York City; San Francisco, California; and Rhode Island (2017–2018)
Beeler Asay GR, Lam CK, Stewart B, et al. Am J Public Health. 2020;110(11):1696-1703.
Nov 2020
USAMulti-city
13
RCT
Smartphone-enabled Video-Observed versus Directly Observed Treatment for Tuberculosis: A Multicentre, Analyst-blinded, Randomised, Controlled Superiority Trial
Story A, Aldridge RW, Smith CM, et al. Lancet. 2019;393(10177):1216-1224.
VOT was superior to in-person DOT (75% vs 60% completing 80%+ of scheduled observations) across 22 clinics: more acceptable, effective, and cheaper than DOT.
Mar 2019
UKLondon
14
Use of Video Directly Observed Treatment for Tuberculosis in Northern Norway
Bendiksen R, Ovesen T, Asfeldt AM, et al. Tidsskr Nor Laegeforen. 2020;140(1).
Jan 2020
NorwayEurope
15
Use of Smartphone-Based Video Directly Observed Therapy (vDOT) in Tuberculosis Care: Single-Arm, Prospective Feasibility Study
Holzman SB, Atre S, Sahasrabudhe T, et al. JMIR Form Res. 2019;3(3):e13411.
Sep 2019
IndiaAsia
16
Change in Patient Comfort Using Mobile Phones Following the Use of an App to Monitor Tuberculosis Treatment Adherence: Longitudinal Study
Do D, Garfein RS, Cuevas-Mota J, Collins K, Liu L. JMIR Mhealth Uhealth. 2019;7(2):e11638.
Feb 2019
USACalifornia
17
Video-Observed Therapy for Tuberculosis: Strengthening Care
Fraser H, Keshavjee S. Lancet. 2019;393(10177):1180-1181.
Mar 2019
GlobalCommentary
18
Synchronous and Asynchronous Video Observed Therapy (VOT) for Tuberculosis Treatment Adherence Monitoring and Support
Garfein RS, Doshi RP. J Clin Tuberc Other Mycobact Dis. 2019;17:100098.
Dec 2019
USAReview
19
Tuberculosis Treatment Monitoring by Video Directly Observed Therapy in 5 Health Districts, California, USA
Garfein RS, Liu L, Cuevas-Mota J, et al. Emerg Infect Dis. 2018;24(10):1806-1815.
VDOT adherence was 93% vs 66% for in-person DOT, at 32% lower cost: feasible, acceptable, and achieving high adherence across 5 California health districts.
Oct 2018
USACalifornia
20
Using Video Technology to Increase Treatment Completion for Patients With Latent Tuberculosis Infection on 3-Month Isoniazid and Rifapentine: An Implementation Study
Lam CK, McGinnis Pilote K, Haque A, Burzynski J, Chuck C, Macaraig M. J Med Internet Res. 2018;20(11):e287.
Nov 2018
USANew York City
21
Advancing Patient-Centered Care in Tuberculosis Management: A Mixed-Methods Appraisal of Video Directly Observed Therapy
Holzman SB, Zenilman A, Shah M. Open Forum Infect Dis. 2018;5(4):ofy046.
Apr 2018
USAMulti-site
22
Video Directly Observed Therapy: Enhancing Care for Patients with Active Tuberculosis
Ingram D. Nursing. 2018;48(5):64-66.
May 2018
USAClinical Practice
23
Video-observed Treatment for Tuberculosis Patients in Belarus: Findings from the First Programmatic Experience
Sinkou H, Hurevich H, Rusovich V, et al. Eur Respir J. 2017;49(3):1602049.
Mar 2017
BelarusEurope
24
Video Directly Observed Therapy to Support Adherence with Treatment for Tuberculosis in Vietnam: A Prospective Cohort Study
Nguyen TA, Pham MT, Nguyen TL, et al. Int J Infect Dis. 2017;65:85-89.
71.1% of patients took all required doses; median 88.4% of doses correctly recorded. VDOT was feasible and resulted in high adherence in a resource-limited outpatient setting.
Dec 2017
VietnamAsia
25
Use of Video Directly Observed Treatment for Tuberculosis in Johnson County, Kansas, 2015
Holzschuh EL, Province S, Johnson K, et al. MMWR Morb Mortal Wkly Rep. 2017;66(14):387-389.
Apr 2017
USAKansas
26
Enhancing Management of Tuberculosis Treatment with Video Directly Observed Therapy in New York City
Chuck C, Robinson E, Macaraig M, Alexander M, Burzynski J. Int J Tuberc Lung Dis. 2016;20(5):588-593.
May 2016
USANew York City
27
Feasibility of Tuberculosis Treatment Monitoring by Video Directly Observed Therapy: a Binational Pilot Study
Garfein RS, Collins K, Muñoz F, et al. Int J Tuberc Lung Dis. 2015;19(9):1057-1064.
Sep 2015
USA / MexicoBinational
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